Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders

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Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders

Accumulating evidence points to the association of epilepsy, particularly, temporal lobe epilepsy (TLE), with psychiatric disorders, such as schizophrenia. Among these illnesses, the hippocampus is considered the regional focal point of the brain, playing an important role in cognition, psychosis, and seizure activity and potentially suggesting common etiologies and pathophysiology of TLE and s...

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Comparison of temporal lobe epilepsy with hippocampal sclerosis and temporal lobe epilepsies due to other etiologies

  Background: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies.   Methods : In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatient epilepsy clinic at Shiraz University of Medical Sc...

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Pathophysiology of mood disorders in temporal lobe epilepsy.

OBJECTIVE There is accumulating evidence that the limbic system is pathologically involved in cases of psychiatric comorbidities in temporal lobe epilepsy (TLE) patients. Our objective was to develop a conceptual framework describing how neuropathological, neurochemical and electrophysiological aspects might contribute to the development of psychiatric symptoms in TLE and the putative neurobiol...

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Psychiatric disorders in temporal lobe epilepsy: the laterality effect.

Relationship between the psychiatric diagnosis and the side of temporal EEG focus was analysed in 62 temporal lobe epileptics. Neurotics had right temporal foci significantly more frequently, while there was no such laterality effect in other psychiatric diagnostic groups.

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P8: Temporal Lobe Epilepsy and Mitochondrial Dysfunction

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ژورنال

عنوان ژورنال: Neuroscience Journal

سال: 2018

ISSN: 2314-4262,2314-4270

DOI: 10.1155/2018/4852359